Some medications boost your appetite and lead to weight gain, especially if you take them long-term. These include beta-blockers, used for heart conditions such as high blood pressure and chest pain (angina), and drugs for diabetes, such as insulin and sulfonylureas. Also, certain seizure medicines such as divalproex (Depakote) and carbamazepine (Carbatrol, Tegretol, Epitol), can cause you to gain up to 10 or more pounds. Other anticonvulsants, including gabapentin (Gralise), pregabalin (Lyrica) and vigabatrin (Sabril), increase your hunger.
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Some antidepressants also can make you gain weight, such as SSRIs and tricyclic antidepressants, which affect the amount of serotonin in your brain. weight gain pills can cause you to feel hungry and to eat more, or it can change your metabolism so that you store calories more easily. In some cases, you can switch to a different type of antidepressant that has less effect on your weight.
Some psychiatric medicines, such as the antipsychotics olanzapine (Zyprexa), quetiapine (Seroquel) and risperidone (Risperdal), can cause you to gain weight by promoting mood changes that lead to eating more and not exercising. But some of these are life-saving, so you should not stop taking them without your doctor’s advice.